A small cut can quickly heal on its own in a few days without leaving a scar.
After the wound is stopped bleeding, immune cells will rush there, mobilizing blood vessel cells to rebuild your capillaries, recruiting new skin cells to help you heal the wound and even
Unfortunately, this mechanism does not work well with large injuries, such as when someone suffers a car accident, surgical incisions, or wounds from an assault weapon on the battlefield.
To overcome this problem, a research team at Johns Hopkins University of Medicine, USA has developed a special injectable gel, reinforced with nanofibers.
Currently, this gel has been successfully tested on mice and rabbits.
`Soft tissue loss is a common problem in clinical medicine,` said Sashank Reddy, a reconstructive surgeon from Johns Hopkins University of Medicine in Baltimore, Maryland, USA.
One is that they may choose to transplant tissue from another area of the patient’s body to the wound site.
The second option is to implant synthetic artificial tissues.
`As a plastic surgeon, every day I see patients who have lost soft tissue such as skin, fat and muscle due to cancer surgery, trauma or other conditions. Currently, our options are
To treat scars, doctors must remove fat from one part to another using a process called fat grafting.
The most advanced technique for regenerating damaged tissue areas is gellike fillers.
It is a gel that macrophage immune cells can get inside.
But this is only effective for small wounds, and with larger wounds in tissue, HA gels are often too weak to hold their shape.
But too many molecular bonds block the passage of macrophages and other cells.
Now, Dr. Reddy and his colleagues have come up with a better solution to reinforce the HA gel.
They then treated the fibers so they could bond with the HA gel, creating a gel that is as elastic as soft tissue.
To test their material, Dr. Reddy and colleagues injected it into mice and rabbits.
Everything was not unexpected, animals that were only injected with HA gel were unable to recover from wounds larger than 1 cm in size.
The research results were published by Dr. Reddy and colleagues in the journal ScienceTranslational Medicine.
`This new gel is a scientific breakthrough,` said Ali Khademhosseini, a biology expert at the University of California, Los Angeles.
Instead, this gel only supports the body in healing wounds in the most natural way.
The gel can also help repair soft tissues inside organs, such as heart muscle cells.
With this vision, Dr. Reddy’s research team hopes they will be able to move forward with testing on real people this year or next.
`As an engineer, our job is to invent something, then try to apply it in real life,` Hai-Quan Mao said.
References Science, Hopkinsmedicine